How does Sotalol work? - MedicineHow

How does Sotalol work?

How does Sotalol work

Sotalol works to control the rhythm of the heart by increasing the refractory period and blocking beta receptors in the heart. This means that the rate of the heart is decreased and it is less likely that the heart will beat uncontrollably fast.

Brand Names and Doses

Brand Dose IconSotalol is the generic name of the drug – the name of the actual component that has an effect in your body. You might know it better by one of the brand names, the names given by the manufacturing company:

  • Solavert (80 mg)
  • Sotacor (80 mg)
  • Cardol (160 mg)

When you take the oral form of sotalol, you will usually take a tablet twice a day (for example, in the morning and at night). This is to make sure that the concentration of the drug and the effect on your body is more constant.

Most people start with a low dose such as 40 or 80 mg twice a day and, if needed, it can be increased up to 160 mg a day. This helps to decrease the risk of side effects when you are beginning to take the medication as your body gets used to the drug.

Sotalol is also available as an injection for emergency use in a hospital environment. Sotacor is the brand of the 10 mg/mL injection.

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What is it used for?

Uses IconSotalol is usually used to treat or prevent irregular heartbeat, which we call arrhythmia.

There are several different types of arrhythmia, according to the area of the heart that isn’t functioning properly and that is causing problems. It might be used for:

  • Atrial arrhythmias
  • Supraventricular arrhythmias
  • Ventricular arrhythmias

How does Sotalol work?

How it works IconSotalol has two main ways that it can work to change the rhythm of the heartbeats: blocking beta receptors and prolonging the action potential.

Firstly, there are beta blockers in many areas around the body, including the heart and the lungs. Sotalol can block these receptors in the heart and cause the heart muscle to contract and beat less often. (It can also block the beta receptors in the lungs, but we’ll cover that in the side effects.)

Secondly, it increases the refractory period of the atria, ventricles and bypass tract in the heart. What is the refractory period? Essentially, electrical impulses are needed to cause the muscle cells to contract together and there is a “rest” period between each beat called the refractory period. Sotalol increases the time of this period, making it more difficult for the heart to beat as often as it usually does.

Side Effects

Side Effects IconThe more serious side effect of sotalol is that it can cause or worsen arrhythmias, particularly if the dose is too high. Therefore, it’s important that we only use sotalol if we really need it because it could do more damage than good.

Another significant side effect is shortness of breath, which can happen when sotalol blocks the beta receptors in the lungs, causing the airways to constrict and making it harder for you to breathe. This is most problematic if you already have issues with breathing, for example if you have asthma or COPD.

Other side effects may include:

  • Low heart rate
  • Low blood pressure
  • Fatigue
  • Drowsiness
  • Dizziness
  • Headache
  • Visual disturbances
  • Heartburn
  • Gastrointestinal effects (e.g. nausea and vomiting)

Most of these effects occur if the dose is too high so, if you do notice these while taking sotalol, you should see your doctor to talk about the right dose for you.


Cautions IconThere are some people who shouldn’t take sotalol, as it can have worse effects for them. It is not likely to be a good choice if you have:

  • Second or third-degree heart block (without a pacemaker)
  • Sinus bradycardia (without a pacemaker)
  • Cardiogenic shock
  • Severe hypotension
  • Prolonged QT interval
  • Severe heart failure
  • Asthma

Addition there are some people who can take sotalol, but need to be more aware of particular effects that might occur. This include if you have an electrolyte imbalance, peripheral vascular disease, Raynaud’s phenomenon, diabetes or phaeochromocytoma.

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Pregnancy and Breastfeeding

Pregnancy IconSotalol can sometimes be used by pregnant women, although only if it is completely necessary. This is because it may have an effect on the fetus, so signs of adverse effects in your baby should be closely monitored.

It can also sometimes be used with caution by women who are breastfeeding. However, a significant concentration of the drug is excreted in the breast milk, so it is important to monitor for signs in the baby closely.

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How does Sotalol work?

About the author


Yolanda is a passionate medical writer who loves to help people understand how health and different treatments work. After graduating in Pharmacy in Australia, she moved to Italy to study the Mediterranean way of life and continue learning about health and medicine.


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